Archive for category Research into Homeopathy

Undue industry influences that distort healthcare research, strategy, expenditure and practice: a review

Conflict of InterestsUndue industry influences that distort healthcare research, strategy, expenditure and practice: a review European Journal of Clinical Investigation, Volume 43, Issue 5, pages 469–475, May 2013. Emmanuel Stamatakis1,2,, Richard Weiler3, John P.A. Ioannidis4,5, Article first published online: 25 MAR 2013

See also http://avilian.co.uk/2012/09/14/false-positives-fraud-and-misconduct-are-threatening-scientific-research/

See also http://avilian.co.uk/2013/10/18/secrets-of-trial-data-revealed-records-of-side-effects-seen-in-clinical-tests-are-missing-from-publicly-available-documents/

From http://onlinelibrary.wiley.com/doi/10.1111/eci.12074/full

Abstract: Background: Expenditure on industry products (mostly drugs and devices) has spiraled over the last 15 years and accounts for substantial part of healthcare expenditure. The enormous financial interests involved in the development and marketing of drugs and devices may have given excessive power to these industries to influence medical research, policy, and practice.

Material and methods: Review of the literature and analysis of the multiple pathways through which the industry has directly or indirectly infiltrated the broader healthcare systems. We present the analysis of the industry influences at the following levels: (i) evidence base production, (ii) evidence synthesis, (iii) understanding of safety and harms issues, (iv) cost-effectiveness evaluation, (v) clinical practice guidelines formation, (vi) healthcare professional education, (vii) healthcare practice, (viii) healthcare consumer’s decisions.

Results: We located abundance of consistent evidence demonstrating that the industry has created means to intervene in all steps of the processes that determine healthcare research, strategy, expenditure, practice and education. As a result of these interferences, the benefits of drugs and other products are often exaggerated and their potential harms are downplayed, and clinical guidelines, medical practice, and healthcare expenditure decisions are biased. 

Conclusion: To serve its interests, the industry masterfully influences evidence base production, evidence synthesis, understanding of harms issues, cost-effectiveness evaluations, clinical practice guidelines and healthcare professional education and also exerts direct influences on professional decisions and health consumers. There is an urgent need for regulation and other action towards redefining the mission of medicine towards a more objective and patient-, population- and society-benefit direction that is free from conflict of interests.  Read the rest of this entry »

HRI Barcelona 2013: A significant step forward for homeopathy research worldwide

Homeopathy Research Institute

HRI Barcelona 2013 – Key Facts
• 180 delegates from over 30 countries
• Presenters from over 20 countries
• 42 oral presentations + 25 posters
• Diverse programme included basic research, fundamental research, clinical research, qualitative
research, pathogenetic trials, disease prevention, veterinary research and ethics

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Flu Patients Happier With Homeopathic Treatment than Allopathic Treatment (France: 2009–2010)

happyWith thanks to The Journal of Alternative and Complementary Medicine and The Complementary Medical Association 18.9.13:

From http://online.liebertpub.com/doi/abs/10.1089/acm.2011.0706 See also http://www.the-cma.org.uk/Articles/Flu-Patients-Happier-With-Homeopathic-Treatment-than-Allopathic-Treatment-(France-20092010)-4903/?utm_source=Sign-Up

‘… Management of Influenza-Like Illness by Homeopathic and Allopathic General Practitioners in France During the 2009–2010 Influenza Season, Stéphane Vincent, Antoine Demonceaux, Didier Deswarte, Daniel Scimeca, and Marie-France Bordet. The Journal of Alternative and Complementary Medicine. February 2013, 19(2): 146-152. doi:10.1089/acm.2011.0706. ‘… In France, homeopathy is widely accepted for the treatment of ILI and does not preclude the use of allopathic medications. However, patients treated with homeopathic medications only are more satisfied with their treatment than other patients…’ Read the rest of this entry »

Majority support for homeopathy in Britain?

MajorityWith thanks to The National Centre for Research Methods and Methods News Winter 2012:

From http://www.ncrm.ac.uk/news/show.php?article=5305 Article by Paul Stoneman and Patrick Sturgis from the NCRM Hub, University of Southampton. This article also appears in the Winter 2012 issue of the MethodsNews newsletter (opens a .pdf file).

The appropriate place for Complementary and Alternative Medicines (CAM) in modern healthcare continues to emerge as a source of controversy in policy debates. The issue attracted media attention again recently, following the appointment in 2012 of the new Secretary of State for Health, Jeremy Hunt, who supports the availability of homeopathic cures through the NHS. Read the rest of this entry »

Good medicine: homeopathy

With thanks to Christopher M Johnson, The British Medical Journal 27.11.12:

From http://www.bmj.com/content/345/bmj.e6184/rr/616928‘… Once again it must be said that what passes for ‘scientific’ discussion amongst homeopathic critics is almost entirely lacking in substance. Scientific statements, by definition, must be precise and testable. Unfortunately, criticisms of homeopathy rarely pass this test. Read the rest of this entry »

The agent Latrodectus and canine paecilomycotic eclampsia as a laboratory model in the survey of treatment for mycoses and parasitic diseases

[The agent Latrodectus and canine paecilomycotic eclampsia as a laboratory model in the survey of treatment for mycoses and parasitic diseases]. [Article in Russian] [No authors listed]Med Parazitol (Mosk). 2012 Apr-Jun;(2):36-9.

Abstract: The extragent used to prepare a Latrodectus mactans hydrocarbon extract is a multicomponent system composed of alkanes, alkenes, and arenes. More than 100 compounds were identified in the hydrocarbon extract (petroleum).

The petroleum matrix of Latrodectus mactans was first obtained to manufacture homeopathic remedies. The authors could prepare the first Russian homeopathic medicine from Latrodectus mactans, which proved to be effective in treating canine eclampsia.

Canine experiments provide a rationale for the authors’ choice as the only homeopathic remedy among thousand known drugs to treat female eclampsia. It is Latrodectus mactans that is in the list of homeopathic medicines permitted for use in accordance with Order No. 335 (Supplement 2) of the Ministry of Health and Medical Industry of Russia, issued on November 29, 1995. It is manufactured from Latrodectus mactans living in the USA.

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[Procedure for Latrodectus reproduction in the laboratory setting and the preparation of the first Russian matrix from its venom to manufacture homeopathic remedies with antiparasitic activity]. [Article in Russian] [No authors listed]Med Parazitol (Mosk). 2012 Apr-Jun;(2):40-5.

Abstract: The investigation was undertaken to study the biology and ecology of Latrodectus, the possibilities of its importation to Russia from other countries, to breed Latrodectus in the laboratory setting, and to design the first homeopathic matrix of Latrodectus to manufacture homeopathic remedies.

The authors were the first to devise a method for Latrodectus breeding in the laboratory setting of Moscow and its vicinities. The Latrodectus bred in the laboratory is suitable to manufacture drugs and in captivity they do not lose its biological activity. The authors were the first to prepare a homeopathic Latrodectus matrix for homeopathic medicines, by using the new Russian extragent petroleum. Chromatography mass spectrometry was used to identify more than a hundred chemical compounds in the Russian petroleum.

The biological activity of the petroleum Latrodectus matrix for the manufacture of homeopathic remedies was highly competitive with that of the traditional Latrodectus venom matrix made using ethyl alcohol. The homeopathic Latrodectus matrix made using glycerol lost its biological activity because of glycerol.

The biological activity of homeopathic matrixes made from Latrodectus inhabiting the USA, Uzbekistan, and the south of Russia and from that bred in the laboratory was studied. The homeopathic matrix made from the Latrodectus living in the Samarkand Region, Republic of Uzbekistan, has the highest biological activity.

The targets of information-carrying nanodomains

The targets of information-carrying nanodomains. Czerlinski G, Ypma T. Source Department of Biology, Western Washington University, Bellingham, WA 98225, USA.J Nanosci Nanotechnol. 2012 Mar;12(3):2239-47.

Abstract: We recently introduced the concept of aqueous nanodomains to explain high potentization in homeopathy.

These long-lived nanodomains carry excited states of at least two ranges of energy packets; one for chemical change, the other for target-information.

Here we discuss how these nanodomains interact with their targets. Our assumption is that these targets are similar to nanodomains, thereby enhancing their interaction.

We use a simple system involving only one enzyme reaction to model the normal, the diseased and the enhanced recovery phases. For the healthy phase, a range of initial enzyme concentrations lead to a stationary state.

We adjust the initial enzyme concentration to find an ‘ideal’ value, for which at stationary state the enzyme cycle provides the identical substrate concentration for each of the adjoining components.

We simulate the diseased phase by starting a fast isomerization between the free active enzyme and its inactive form. At the end of this phase another stationary state is reached. In the subsequent recovery phase the fast movement of the excited states in the homeopathic solution rapidly converts the inactive form of the enzyme to its electronically excited state, which then converts to active free enzyme.

At the end of this phase we return to the stationary state reached at the end of the healthy phase, that is, complete recovery to health.

This simple model omits many of the complexities of a live organism. However, the elements of homeopathic action at the target can be observed clearly, as shown by a number of simulations.

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Impact of physician preferences for homeopathic or conventional medicines on patients with musculoskeletal disorders: results from the EPI3-MSD cohort

Impact of physician preferences for homeopathic or conventional medicines on patients with musculoskeletal disorders: results from the EPI3-MSD cohort. Rossignol M, Begaud B, Engel P, Avouac B, Lert F, Rouillon F, Bénichou J, Massol J, Duru G, Magnier AM, Guillemot D, Grimaldi-Bensouda L, Abenhaim L; for the EPI3-LA-SER group.harmacoepidemiol Drug Saf. 2012 Jul 11. doi: 10.1002/pds.3316. [Epub ahead of print]. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada; LA-SER Centre for Risk Research, Montreal, Canada. Michel.Rossignol@CRR-Intl.com.

Abstract

OBJECTIVE: The objective of this study was to assess the effect of physician practicing preferences (PPP) in primary care for homeopathy (Ho), CAM (Complementary and alternative medicines) with conventional medicine (Mx) or exclusively conventional medicine (CM) on patients with musculoskeletal disorders (MSDs), with reference to clinical progression, drug consumption, side effects and loss of therapeutic opportunity.

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Changes in chronic low back pain and cardiovascular risk factors using a homeopathic human chorionic gonadotropin-based weight loss program: a case report

Changes in chronic low back pain and cardiovascular risk factors using a homeopathic human chorionic gonadotropin-based weight loss program: a case report. Morningstar MW, Strauchman MN. Chiropractor, Private Practice of Chiropractic Medicine, Natural Wellness and Pain Relief Centers of Michigan, Grand Blanc, MI 48439. J Chiropr Med. 2011 Dec;10(4):322-326.

Abstract

OBJECTIVE: The purpose of this case report is to describe the changes in body weight and biochemical markers in a patient who completed a homeopathic human chorionic gonadotropin protocol.

CASE REPORT: A 52-year-old man reported to an integrative medical center (including chiropractic and osteopathic physicians) for chronic low back pain. The patient reported a 20-year history of chronic, episodic low back pain. A course of spinal manipulative therapy was delivered; however, because of the lack of resolution of symptoms, a radiographic examination was performed, the result of which was essentially normal. Laboratory studies demonstrated hypercholesterolemia, hyperlipidemia, uricemia, and elevated blood glucose. A dietary change in treatment approach was selected.

INTERVENTION AND OUTCOME: The patient was instructed to take 10 drops of a homeopathic human chorionic gonadotropin product under the tongue 5 times daily. His total daily energy (calorie) was limited for the first 30 days of the program while on the homeopathic product. After 4 months, the patient lost a total of 71 lb, pain and disability scores improved, and reductions in serum cardiovascular markers were noted.

CONCLUSION: The findings of this study showed that weight loss seemed to affect the patient’s chronic low back pain and cardiovascular risk factors.

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Adverse drug reactions to anthroposophic and homeopathic solutions for injection: a systematic evaluation of German pharmacovigilance databases

Adverse drug reactions to anthroposophic and homeopathic solutions for injection: a systematic evaluation of German pharmacovigilance databases. Jong MC, Jong MU, Baars EW. Department Healthcare and Nutrition, Louis Bolk Institute, Driebergen, The Netherlands; Department Health Sciences, Mid Sweden University, Sundsvall, Sweden. m.jong@louisbolk.nl. Pharmacoepidemiol Drug Saf. 2012 Jun 13. doi: 10.1002/pds.3298.

Abstract

PURPOSE: Medicinal solutions for injection are frequently applied in anthroposophic medicine and homeopathy. Despite their extensive use, there is little data published on the safety of these products. Therefore, we investigated the safety of anthroposophic and homeopathic solutions for injection through a systematic evaluation of adverse drug reactions (ADRs).

METHODS: ADRs were extracted from the pharmacovigilance databases of eight German manufacturers. Analysed ADRs included case reports in humans only, (spontaneous) case reports from post-marketing surveillance, literature and clinical/safety trials.

RESULTS: Between 2000 and 2009, in total, 303 million ampoules for injection were sold, and 486 case reports were identified, corresponding to a total number of 1180 ADRs. Of all case reports, 71.8% (349/486) included ADRs that were listed (e.g. stated in package leaflet), and 9.5% (46/486) of the reports were classified as serious. The most frequently reported ADRs were pruritus, followed by angioedema, diarrhoea and erythema. A total of 27.3% (322/1180) were localized reactions for example; application or injection site erythema, pain, swelling and inflammation. The overall reporting rate of ADRs associated with injections was less than 4 per 1 million sold ampoules and classified as very rare.

CONCLUSIONS: Our systematic evaluation demonstrated that the reporting rate of ADRs associated with anthroposophic and homeopathic solutions for injection is very low. Most reported ADRs were listed, and one quarter consisted of local reactions. These findings suggest a low risk profile for solutions for injection as therapeutically applied in anthroposophic medicine and homeopathy.

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