Archive for category Research into Homeopathy

The targets of information-carrying nanodomains

The targets of information-carrying nanodomains. Czerlinski G, Ypma T. Source Department of Biology, Western Washington University, Bellingham, WA 98225, USA.J Nanosci Nanotechnol. 2012 Mar;12(3):2239-47.

Abstract: We recently introduced the concept of aqueous nanodomains to explain high potentization in homeopathy.

These long-lived nanodomains carry excited states of at least two ranges of energy packets; one for chemical change, the other for target-information.

Here we discuss how these nanodomains interact with their targets. Our assumption is that these targets are similar to nanodomains, thereby enhancing their interaction.

We use a simple system involving only one enzyme reaction to model the normal, the diseased and the enhanced recovery phases. For the healthy phase, a range of initial enzyme concentrations lead to a stationary state.

We adjust the initial enzyme concentration to find an ‘ideal’ value, for which at stationary state the enzyme cycle provides the identical substrate concentration for each of the adjoining components.

We simulate the diseased phase by starting a fast isomerization between the free active enzyme and its inactive form. At the end of this phase another stationary state is reached. In the subsequent recovery phase the fast movement of the excited states in the homeopathic solution rapidly converts the inactive form of the enzyme to its electronically excited state, which then converts to active free enzyme.

At the end of this phase we return to the stationary state reached at the end of the healthy phase, that is, complete recovery to health.

This simple model omits many of the complexities of a live organism. However, the elements of homeopathic action at the target can be observed clearly, as shown by a number of simulations.

Read about more about scientific research on homeopathy

Impact of physician preferences for homeopathic or conventional medicines on patients with musculoskeletal disorders: results from the EPI3-MSD cohort

Impact of physician preferences for homeopathic or conventional medicines on patients with musculoskeletal disorders: results from the EPI3-MSD cohort. Rossignol M, Begaud B, Engel P, Avouac B, Lert F, Rouillon F, Bénichou J, Massol J, Duru G, Magnier AM, Guillemot D, Grimaldi-Bensouda L, Abenhaim L; for the EPI3-LA-SER group.harmacoepidemiol Drug Saf. 2012 Jul 11. doi: 10.1002/pds.3316. [Epub ahead of print]. Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada; LA-SER Centre for Risk Research, Montreal, Canada. [email protected]

Abstract

OBJECTIVE: The objective of this study was to assess the effect of physician practicing preferences (PPP) in primary care for homeopathy (Ho), CAM (Complementary and alternative medicines) with conventional medicine (Mx) or exclusively conventional medicine (CM) on patients with musculoskeletal disorders (MSDs), with reference to clinical progression, drug consumption, side effects and loss of therapeutic opportunity.

Read about more about scientific research on homeopathy

Read the rest of this entry »

Changes in chronic low back pain and cardiovascular risk factors using a homeopathic human chorionic gonadotropin-based weight loss program: a case report

Changes in chronic low back pain and cardiovascular risk factors using a homeopathic human chorionic gonadotropin-based weight loss program: a case report. Morningstar MW, Strauchman MN. Chiropractor, Private Practice of Chiropractic Medicine, Natural Wellness and Pain Relief Centers of Michigan, Grand Blanc, MI 48439. J Chiropr Med. 2011 Dec;10(4):322-326.

Abstract

OBJECTIVE: The purpose of this case report is to describe the changes in body weight and biochemical markers in a patient who completed a homeopathic human chorionic gonadotropin protocol.

CASE REPORT: A 52-year-old man reported to an integrative medical center (including chiropractic and osteopathic physicians) for chronic low back pain. The patient reported a 20-year history of chronic, episodic low back pain. A course of spinal manipulative therapy was delivered; however, because of the lack of resolution of symptoms, a radiographic examination was performed, the result of which was essentially normal. Laboratory studies demonstrated hypercholesterolemia, hyperlipidemia, uricemia, and elevated blood glucose. A dietary change in treatment approach was selected.

INTERVENTION AND OUTCOME: The patient was instructed to take 10 drops of a homeopathic human chorionic gonadotropin product under the tongue 5 times daily. His total daily energy (calorie) was limited for the first 30 days of the program while on the homeopathic product. After 4 months, the patient lost a total of 71 lb, pain and disability scores improved, and reductions in serum cardiovascular markers were noted.

CONCLUSION: The findings of this study showed that weight loss seemed to affect the patient’s chronic low back pain and cardiovascular risk factors.

Read about more about scientific research on homeopathy

Adverse drug reactions to anthroposophic and homeopathic solutions for injection: a systematic evaluation of German pharmacovigilance databases

Adverse drug reactions to anthroposophic and homeopathic solutions for injection: a systematic evaluation of German pharmacovigilance databases. Jong MC, Jong MU, Baars EW. Department Healthcare and Nutrition, Louis Bolk Institute, Driebergen, The Netherlands; Department Health Sciences, Mid Sweden University, Sundsvall, Sweden. [email protected] Pharmacoepidemiol Drug Saf. 2012 Jun 13. doi: 10.1002/pds.3298.

Abstract

PURPOSE: Medicinal solutions for injection are frequently applied in anthroposophic medicine and homeopathy. Despite their extensive use, there is little data published on the safety of these products. Therefore, we investigated the safety of anthroposophic and homeopathic solutions for injection through a systematic evaluation of adverse drug reactions (ADRs).

METHODS: ADRs were extracted from the pharmacovigilance databases of eight German manufacturers. Analysed ADRs included case reports in humans only, (spontaneous) case reports from post-marketing surveillance, literature and clinical/safety trials.

RESULTS: Between 2000 and 2009, in total, 303 million ampoules for injection were sold, and 486 case reports were identified, corresponding to a total number of 1180 ADRs. Of all case reports, 71.8% (349/486) included ADRs that were listed (e.g. stated in package leaflet), and 9.5% (46/486) of the reports were classified as serious. The most frequently reported ADRs were pruritus, followed by angioedema, diarrhoea and erythema. A total of 27.3% (322/1180) were localized reactions for example; application or injection site erythema, pain, swelling and inflammation. The overall reporting rate of ADRs associated with injections was less than 4 per 1 million sold ampoules and classified as very rare.

CONCLUSIONS: Our systematic evaluation demonstrated that the reporting rate of ADRs associated with anthroposophic and homeopathic solutions for injection is very low. Most reported ADRs were listed, and one quarter consisted of local reactions. These findings suggest a low risk profile for solutions for injection as therapeutically applied in anthroposophic medicine and homeopathy.

Read about more about scientific research on homeopathy

Identification of Medicinally Active Ingredient in Ultradiluted Digitalis purpurea: Fluorescence Spectroscopic and Cyclic-Voltammetric Study

Identification of Medicinally Active Ingredient in Ultradiluted Digitalis purpurea: Fluorescence Spectroscopic and Cyclic-Voltammetric Study. Sharma A, Purkait B. Indian Institute of Technology, Kharagpur, Kharagpur 721302, India. J Anal Methods Chem. 2012;2012:109058. Epub 2012 Mar 26.

Abstract: Serially diluted and agitated (SAD) drugs available commercially are in use with great faith because of the astonishing results they produce. The scientific viewpoint attached to the centuries-old therapy with SAD drugs, as in homeopathy, remained doubtful for want of appropriate research and insufficient evidence base.

The conflicting points related to SAD drug mostly related to the level of concentrations/dilutions, use of drug in contradictory clinical conditions compared to the modern system of medicine, identification of medicinally active ingredient in concentrations and dilutions used in commercially available SAD drugs, and lack of laboratory-based pharmacological data vis-à-vis modern medicine. Modus operandi of SAD drug is also unknown.

To address some of these issues an analytical study was carried out wherein commercially available SAD drug Digitalis purpurea, commonly used in different systems of medicine, was put to test. Various concentrations of commercially available Digitalis purpurea were analyzed using analytical methods: cyclic voltammetry, emission spectroscopy, and UV-VIS spectroscopy.

These analytical methods apparently identified the medicinal ingredients and effect of serial dilution in commercial preparation of the drugs.

Read about more about scientific research on homeopathy

Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies

Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies. Bellavite P, Conforti A, Marzotto M, Magnani P, Cristofoletti M, Olioso D, Zanolin ME. Source Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy. Evid Based Complement Alternat Med. 2012;2012:954374. Epub 2012 Apr 4.

Abstract: Two previous investigations were performed to assess the activity of Gelsemium sempervirens (Gelsemium s.) in mice, using emotional response models. These two series are pooled and analysed here.

Gelsemium s. in various homeopathic centesimal dilutions/dynamizations (4C, 5C, 7C, 9C, and 30C), a placebo (solvent vehicle), and the reference drugs diazepam (1 mg/kg body weight) or buspirone (5 mg/kg body weight) were delivered intraperitoneally to groups of albino CD1 mice, and their effects on animal behaviour were assessed by the light-dark (LD) choice test and the open-field (OF) exploration test.

Up to 14 separate replications were carried out in fully blind and randomised conditions. Pooled analysis demonstrated highly significant effects of Gelsemium s. 5C, 7C, and 30C on the OF parameter “time spent in central area” and of Gelsemium s. 5C, 9C, and 30C on the LD parameters “time spent in lit area” and “number of light-dark transitions,” without any sedative action or adverse effects on locomotion.

This pooled data analysis confirms and reinforces the evidence that Gelsemium s. regulates emotional responses and behaviour of laboratory mice in a nonlinear fashion with dilution/dynamization.

Read about more about scientific research on homeopathy

Phenotypic evidence of ultra-highly diluted homeopathic remedies acting at gene expression level: a novel probe on experimental phage infectivity in bacteria

Phenotypic evidence of ultra-highly diluted homeopathic remedies acting at gene expression level: a novel probe on experimental phage infectivity in bacteria. Saha SK, Das S, Khuda-Bukhsh AR. Source Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, India; E-mail: [email protected], [email protected] Zhong Xi Yi Jie He Xue Bao. 2012 Apr;10(4):462-70.

Abstract

OBJECTIVE: To explore if some ultra-highly diluted homeopathic remedies claimed to have antiviral effects can demonstrate any discernible action in the bacteria Escherichia coli through modulating infectivity potentials of the bacteriophage φX174 DNA.

METHODS: φX174 was selected because of its known host specificity to E. coli and its constitutive expression of lytic gene E when inside the bacterial host. We deployed the “bacteriophage assay system” by “top layer agar plating” method of plaque-counting for evaluation of efficacy of the homeopathic remedies in rendering the bacteria’s protective ability against the attack of φX174. The plaque number in the agar-plated Petri dishes, either containing the phage-bacteria mixture subjected to one of the diluted homeopathic drugs under test (1% volume ratio; Belladonna 30C, Rhus Tox 30C, Arnica 30C) or the succussed 1% “alcoholic vehicle” of the drug was recorded. The plaques represented the bacterial colony actually infected and lysed by φX174. Conversely, we subjected φX174 to the homeopathic drug treatment before allowing them to interact with the bacteria to ascertain if the drug itself had any direct effect on the infective potential of the phage DNA entering into the bacterial cell.

RESULTS: Each homeopathic remedy showed a significant decrease in plaque number on pretreated bacteria (1 h prior to infection) with respect to untreated and placebo-treated controls; there was only an insignificant change in the plaque number when φX174 was pretreated with the drugs. As φX174 starts lytic cycle when inside the bacterial cell, the loss of plaque number would mean that either the lytic gene E in many was repressed or the entire phage DNA was annihilated by the bacterial gene product (restriction enzymes) known to be regulated by a cluster of genes.

CONCLUSION: This provides phenotypic evidence for the ability of ultra-highly diluted homeopathic remedies to regulate expression of certain gene(s) depending on need of the organism.

Read about more about scientific research on homeopathy

Homeopathic aggravation with Quinquagintamillesimal potencies

Homeopathic aggravation with Quinquagintamillesimal potencies. Rossi E, Bartoli P, Bianchi A, Endrizzi C, Da Frè M. Source Homeopathic Clinic, Local Health Unit n. 2 Lucca, Tuscany Regional Reference Centre, Italy. Homeopathy. 2012 Apr;101(2):112-20.

Abstract

INTRODUCTION: Homeopathic aggravation is the exacerbation of some symptoms or the whole pathological situation, followed by improvement of the patient’s conditions.

AIM: To evaluate the typology, intensity and frequency of homeopathic aggravation, especially with Quinquagintamillesimal (Q, LM) potencies and its prognostic value.

METHODS: The homeopathic prescription strategy evaluated consists in the administration of a single homeopathic medicine in Q dilutions, starting with 6Q, then a progressive scale of Q potencies. Patients whose symptoms could be attributed to a wrong and inappropriate prescription, according to the criteria previously described, were excluded.

RESULTS: Data was collected on 1108 patients consecutively visited from 3rd October 2002 to 31st December 2007, and 441 cases followed for at least 2 months (40% of total cases). 63 of these cases (14%) reported homeopathic aggravation: 7% reported ‘slight’, 5% ‘medium’, 2% ‘intense’ and 0.4% ‘very intense’ aggravation. Homeopathic aggravation was present in 21% of paediatric patients (≤14 years). About 50% of the cases manifested homeopathic aggravation 1 or 2 days after the prescription and for 67% of patients the symptoms lasted 1 week or less. Patients with aggravation of the original disease had significantly greater improvement than those patients showing the aggravation of other, new or different, symptoms or conditions, or no aggravation.

CONCLUSIONS: These data show that homeopathic aggravation with Q potencies is quite frequent in homeopathic clinical practice and seems to be associated with better treatment outcome.

Read about more about scientific research on homeopathy

Effects of two homeopathic complexes on bovine sperm mitochondrial activity

Effects of two homeopathic complexes on bovine sperm mitochondrial activity. Aziz DM, Schnurrbusch U, Enbergs H. Source Institute of Physiology, Biochemistry and Hygiene of Animals, Bonn University, Bonn, Germany. Homeopathy. 2012 Apr;101(2):99-102.

Abstract

OBJECTIVES: This study was conducted to evaluate the effect of two homeopathic complexes Ubichinon compositum(®) (Ubi comp) and Coenzyme compositum ad us. vet.(®) (CoQ10 comp) on bovine sperm mitochondrial activity.

METHODS: Sperm viability, acrosomal integrity and sperm chromatin structure were estimated to detect the possible side effect of complexes on other sperm parameters.

RESULTS: Mitochondrial activity was significantly enhanced by both Ubi comp (P<0.01) and CoQ10 comp (P<0.05). No effects were detected in other tested sperm parameters.

CONCLUSION: The tested homeopathic complex medicines stimulate the mitochondrial activity of bovine sperm without effects on their viability, acrosomal integrity or chromatin structure. The possibility that this translates into improved fertilization capacity in artificial insemination should investigated.

Read about more about scientific research on homeopathy

Effects of Calendula officinalis on human gingival fibroblasts

Effects of Calendula officinalis on human gingival fibroblasts. Saini P, Al-Shibani N, Sun J, Zhang W, Song F, Gregson KS, Windsor LJ. Source Department of Periodontics, Indiana University School of Dentistry, 1121 West Michigan Street, DS 423, Indianapolis, IN 46202, USA. Homeopathy. 2012 Apr;101(2):92-8.

Abstract

BACKGROUND: Calendula officinalis is commonly called the marigold. It is a staple topical remedy in homeopathic medicine. It is rich in quercetin, carotenoids, lutein, lycopene, rutin, ubiquinone, xanthophylls, and other anti-oxidants. It has anti-inflammatory properties. Quercetin, one of the active components in Calendula, has been shown to inhibit recombinant human matrix metalloproteinase (MMP) activity and decrease the expression of tumor necrosis factor-α, interleukin-1β (IL), IL-6 and IL-8 in phorbol 12-myristate 13-acetate and calcium ionophore-stimulated human mast cells.

OBJECTIVES: To examine the effects of Calendula on human gingival fibroblast (HGF) mediated collagen degradation and MMP activity.

MATERIAL AND METHODS: Lactate dehydrogenate assays were performed to determine the non-toxic concentrations of Calendula, doxycycline and quercetin. Cell-mediated collagen degradation assays were performed to examine the inhibitory effect on cell-mediated collagen degradation. Gelatin zymography was performed to examine their effects on MMP-2 activity. The experiments were repeated three times and ANOVA used for statistical analyses.

RESULTS: Calendula at 2-3% completely inhibited the MMP-2 activity in the zymograms. Doxycycline inhibited HGF-mediated collagen degradation at 0.005, 0.01, 0.02 and 0.05%, and MMP-2 activity completely at 0.05%. Quercetin inhibited HGF-mediated collagen degradation at 0.005, 0.01 and 0.02%, and MMP-2 activity in a dose-dependent manner. Calendula inhibited HGF-mediated collagen degradation and MMP-2 activity more than the same correlated concentration of pure quercetin.

CONCLUSION: Calendula inhibits HGF-mediated collagen degradation and MMP-2 activity more than the corresponding concentration of quercetin. This may be attributed to additional components in Calendula other than quercetin.

Read about more about scientific research on homeopathy